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To the Editor:—
There are a number of bismuth preparatious on the market put out by manufacturing chemists in the shape of bismuth creams, milks, etc., purporting to have the same field of usefulness in gastrointestinal disorders as bismuth subnitrate. I believe these preparations are made from the oxid and while, from a pharmaceutical standpoint, they seem to leave nothing to be desired, clinically, I am convinced, they are well nigh worthless, at least in infants.In a series of observatons covering their administration to twenty-one infants suffering from acute gastroenteric conditions, I failed to observe a sedative or astringent action in a singie case. In 21 cases I gave four ounces of a well-known bismuth milk in thirty-six hours to intants suffering from gastroenteritis, with frequent stools containing some blood and abundant mucus, without the slightest appreciable effect in the character or frequency of the stools notwithstanding the fact that milk
Hulse JA. Bismuth Subnitrate Superior to Bismuth Milks. JAMA. 1910;55(3):236. doi:10.1001/jama.1910.04330030058025
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