The internal method of the treatment of hemorrhage has received its most successful presentation from P. E. Weil's report of his results with serum in 1905,1 and from his subsequent articles. He demonstrated that in hemophilia oftentimes the slow coagulation of blood does not result from an anticoagulating ferment, but is due to a lack of, or at least a modification of, certain substances in the blood, as the fibrin ferment. This was shown by him in vitro; first, on the addition to freshly-drawn blood of a small amount of hemophilic serum, the serum did not in the least retard the clotting of the blood, as proved by controls; and secondly, on the addition to freshly drawn hemophilic blood of a small amount of fresh serum from normal blood, the serum caused the hemophilic blood to clot as rapidly as and in a similar manner to normal blood, thus
BIGELOW EB. SERUM TREATMENT OF HEMORRHAGIC DISEASE OF THE NEW-BORNWITH REPORT OF THREE CASES. JAMA. 1910;55(5):400–402. doi:10.1001/jama.1910.04330050038014
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