In selecting a method for the performance of the complement-fixation test of syphilitic sera, we were influenced by several factors, chief of which were the following:
In studying the different methods carefully and comparing the results obtained by different workers, we were impressed by the apparent accuracy of Noguchi's modification of the Wassermann test as shown by Noguchi1, Fox2, Swift3, and others.
It was also much more convenient to secure human than sheep's blood for immunizing our rabbits and for the corpuscle suspension used in the test.
This paper is not intended to criticize any one method or to compare the efficiency of the different methods; but to give the results and conclusions drawn from the examination of four hundred and ten sera by Noguchi's method.
The majority of the patients were private patients of Drs. Hyde and Ormsby. The control specimens of syphilitic blood were secured
WAUGH JF. RESULTS OF EXPERIENCE WITH NOGUCHI MODIFICATION OF THE WASSERMANN SERO-DIAGNOSIS TEST FOR SYPHILIS. JAMA. 1910;55(10):844–848. doi:10.1001/jama.1910.04330100030009
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