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Article
September 17, 1910

PATHOLOGY AND BACTERIOLOGY OF ACUTE ANTERIOR POLIOMYELITIS

JAMA. 1910;55(12):1013-1014. doi:10.1001/jama.1910.04330120035012
Abstract

I. PATHOLOGY  A review of the literature shows records of about 100 autopsies on cases of poliomyelitis, nearly one-half of which were performed years after the acute attack.Our studies include material from six autopsies performed on cases occurring in the Minnesota epidemic of 1909. In the article the cases are reported in detail.The process as a whole follows a definite and specific course. Whatever may be finally shown to be the agent of infection, its "optimus locus" is in the perivascular lymph channels of the anterior portions of the cord, especially those located in the gray matter. From this site the reaction spreads on the one hand to the surrounding tissue spaces of the gray matter and on the other to the lymph channels of the white matter and pia, often involving the posterior portions of the cord.

CONCLUSIONS  1. Acute anterior poliomyelitis is a specific infectious disease

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