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October 1, 1910


JAMA. 1910;55(14):1200. doi:10.1001/jama.1910.04330140044014

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The usual length of time, elapsing between the subcutaneous injection of a dose of diptheria antitoxin and the following skin reaction is given by various writers as varying between twenty-four and seventy-two hours. The following case showed an unusually quick reaction:

History.—  M. K., boy, aged 6, was seen by me twenty-four hours after he was taken ill. I found him in bed with temperature 101.4 F., pulse 104, respiration 23, and complaining of difficulty in swallowing. A pharyngeal examination showed a typical picture of diphtheritic exudate on both tonsils and spreading partly up the pillars of the fauces. A later bacteriologic test by the New York City Department of Health confirmed the diagnosis of diphtheria. I immediately gave a subcutaneous injection of 3,000 units of diphtheria antitoxin of New York City Department of Health into the tissues of the abdominal wall, and after a few minutes left the patient.

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