In December, 1908, an investigation was begun in the Babies' Hospital to determine what information could be gained in respiratory infections from a study of cultures of bronchial secretions. For the first season interest centered on the Bacillus influenzæ to gain, if possible, some definite information as to its frequency and importance in respiratory infections, and also to see what value, if any, could be attached to sputum cultures in the diagnosis of influenza. The first season's observations extended from December, 1908, to June, 1909, and were made on 250 patients and 40 nurses in the of this paper a detailed report concerning the Micrococcus catarrhalis which was found in about two-thirds of the cultures made. Thus far we have not been inclined to consider its presence as significant or important.
During the past season, from the middle of September, 1909, to June 1, 1910, there have been made, from
HOLT LE. THE BACTERIOLOGY OF ACUTE RESPIRATORY INFECTIONS IN CHILDREN AS DETERMINED BY CULTURES FROM THE BRONCHIAL SECRETION. JAMA. 1910;55(15):1241–1246. doi:10.1001/jama.1910.04330150001001
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