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Scientific Discovery and the Future of Medicine
February 24, 2015

Genomic Engineering and the Future of Medicine

Author Affiliations
  • 1Departments of Molecular and Cell Biology and Chemistry, Center for RNA Systems Biology, Innovative Genomics Initiative, University of California, Berkeley
  • 2Howard Hughes Medical Institute, University of California, Berkeley
  • 3Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California
JAMA. 2015;313(8):791-792. doi:10.1001/jama.2015.287

Biology and clinical medicine are in the midst of a remarkable revolution. Technical advances in DNA sequencing have given scientists access to the molecular code governing each individual’s unique characteristics, including disease susceptibility and drug sensitivity. This remarkable knowledge could only inform researchers and clinicians because tools to act on the data by making targeted changes to the human genome were too expensive and cumbersome for widespread practical use. Nonetheless, the compelling promise of truly personalized medicine spurred the quest for methods to achieve precision genomic manipulation.