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December 10, 1910


Author Affiliations

Professor of Medicine and Clinical Medicine in the Medico-Chirurgical College PHILADELPHIA

JAMA. 1910;55(24):2023-2025. doi:10.1001/jama.1910.04330240001001

The vaccine treatment of typhoid fever has been tested in recent years by a number of clinicians with varying results. Fraenkel1 was the first to call attention to the subject of the treatment of this disease by vaccine therapy. Since the commencement of the year 1909, considerable number of other writers have reported individual experiences of the use of typhoid vaccines as a means of cure. While the medical profession is not, in any marked degree, enthusiastic in regard to the question, every new remedy or method of treatment that rests on a reasonably secure, scientific basis deserves an extended trial before its rejected. Certain fundamental principles and facts, which are generally accepted by laboratory experts, should be understood also by the clinician who intends to use vaccines in the treatment of typhoid fever and other diseases. Among these are:

1. The object of vaccine therapy is to induce an active immunity by introducing an added amount of morbific material, so that "by manufacturing an increased amount of the protective bodies, it (the