[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
December 31, 1910


Author Affiliations


JAMA. 1910;55(27):2290-2292. doi:10.1001/jama.1910.04330270012005

I. THE DEVELOPMENT OF FIBROUS TISSUE  The result of some studies in the development of fibrous tissue as observed in wound-healing from a necessary introduction to the consideration of the behavior of connective tissue in its relation to developing epithelium. It will be necessary, therefore, to present in outline some researches already published.2The first change in the healing of any wound is the exudation of a colorless serum. Within a few minutes this material begins to coagulate, forming bands extending from one wound surface to another. These bands become fully formed after a few hours. They take the direction most effectual for union. I speak of this process as coagulation because the fibers so formed stain by Weigert's fibrin stain and stain red by Mallory's stain, as is characteristic for fibrin (and Mallory's fibroglia fibrils), and because those things which prevent the coagulation of blood prevent the formation of these fibrils. We have then a tinctorial and