Pernicious anemia is no longer to be regarded as a rare disease. It is fairly common, and, as Cabot well says, is most common wherever most carefully searched for. As a family affection it appears rare. In a somewhat cursory examination of the literature I have found but few reported instances of multiple cases of the disease in the same family. Ehrlich and Lazarus in their extensive article on "Pernicious Anemia" in Nothnagel's "Encyclopedia of Medicine" state that there is no evidence in the literature that heredity plays any rôle in the origin of the disease. They add: "The report by Sinkler and Eshner, quoted in all books, of three cases of essential anemia in one family, is so incomplete that it is useless. Schmaltz quotes an observation of Klein's who saw a brother and sister succumb to progressive anemia." They make no further mention of multiple cases in single
BARTLETT CJ. FAMILY PERNICIOUS ANEMIA: WITH REPORT OF CASES. JAMA. 1913;60(3):176–179. doi:10.1001/jama.1913.04340030006005
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