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March 1, 1913

Current Comment

JAMA. 1913;60(9):673-675. doi:10.1001/jama.1913.04340090035019

AN INHERITED ANOMALY  Anomalies of form and function are common inborn defects which come to the attention of every physician in the course of his routine of experience. Oddities of human skin color, aside from familiar pigmentation defects or cutaneous blemishes, are less frequently encountered. An interesting variation exhibited by a family of spotted negroes has been described by Simpson and Castle.1 The "piebald" condition of the skin, which is spotted with white in a fairly definite pattern not unlike that of certain domesticated animals, made its appearance as a mutation or sport in a negro family of the Southern United States about sixty years ago. Aside from the immediate peculiarity of this rather unique variation there is decided biologic interest in the fact that it has already shown itself fully hereditary through two generations of offspring. To the student of heredity the data that have been collected in