The changes that occur in the body during the progress of a disease are always of interest and vital importance, and it is worthy of note that from the earliest recognition of pellagra much attention has been given to its pathology. But in spite of painstaking work by numerous investigators, our knowledge of the subject is yet in a somewhat chaotic state. Following the lead of earlier writers, those studying the subject more recently have confined their observations largely to changes in the central nervous system, while the morbid condition of the gastro-intestinal tract, it would seem, has been given insufficient attention. The extent and severity of the lesions vary with the type of the disease present, as do also the symptoms arising from their presence. With our present state of knowledge it would hardy seem possible to decide whether the gastro-intestinal lesions or the changes in the nervous system
MILLS HP. PELLAGRA: WITH SPECIAL REFERENCE TO PATHOLOGY OF GASTROINTESTINAL TRACT. JAMA. 1913;60(12):889–892. doi:10.1001/jama.1913.04340120015006
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