In The Journal of Oct. 12, 1912, the production of active and passive immunity to the pneumococcus in the rabbit with an extract of the living microorganisms by an alkaline solution of pancreatin was described,1 and ten cases of pneumonia were reported in which recovery followed its administration. Since that time, further animal experiments have confirmed these results and recovery has occurred in seven more cases, none of the patients treated having died. In the greater number of cases the crisis has occurred within twenty-four hours after the first dose of the extract.
With the gonococcus, experiments naturally could not be performed on the lower animals, but the clinical material was more abundant. The results thus far obtained are sufficient, however, to warrant a provisional repoit. The extract was prepared in the same manner as the pneumococcic. A suspension of the gonococcus was heated to 38 C. (100.4 F.)
HIRSCHFELDER JO. THE TREATMENT OF GONORRHEAL AND OTHER INFECTIONS WITH DIGESTIVE BACTERIAL EXTRACTS: PRELIMINARY REPORT. JAMA. 1913;60(14):1061–1063. doi:10.1001/jama.1913.04340140023008
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