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Article
April 5, 1913

RABIES: A PATHOGNOMONIC SIGN GENERALLY OVERLOOKED

Author Affiliations

EL PASO, TEXAS

JAMA. 1913;60(14):1069-1070. doi:10.1001/jama.1913.04340140031011

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Abstract

Aside from the pioneer communications on hydrophobia, very little has been written on the subject, and that little is extremely vague and indefinite. Having an opportunity to observe a series of over two hundred rabbits inoculated with rabies (for use in the El Paso Pasteur Institute), as well as a number of animals infected with "street rabies," I was impressed with the uniformity of the development of the symptoms, and particularly of a left hemiplegia starting in the leg (simulating Landry's Paralysis) of which I could find only vague references in the literature.

The first symptom of the disease in the rabbits was a general nervousness; the entire body seemed to be trembling and, if the animal was startled by the sudden clapping of hands, it would stagger and apparently have great trouble in maintaining its balance. Soon a limping of the left hind leg was noticed and, if the rabbit

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