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Article
April 19, 1913

THE RELATIONSHIP OF VARIOLA AND VACCINIA

Author Affiliations

Major, M. C., U. S. A.; President of the United States Army Board for the Study of Tropical Diseases as They Exist in the Philippine Islands WASHINGTON, D. C.

JAMA. 1913;60(16):1220-1221. doi:10.1001/jama.1913.04340160022010

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Abstract

The relationship of variola and vaccinia has been discussed since Jenner's day, but no satisfactory explanation found. Yet there is an explanation so simple, complete and satisfactory that as thorough an investigation of the literature as I have been able to make in Manila in three months does not reveal any evidence in opposition, and does yield an amount of support that seems almost to constitute proof.

I. BASIC FACTS 

  1. 1. Small-pox contagion or inoculation gives rise in man to small-pox, a highly contagious, generalized disease of considerable mortality, characterized ordinarily by a preemptive stage, and other stages related to the appearance, development and subsidence of the eruption.

  2. 2. Passed through monkeys and cattle for a few generations and brought back to man, the virus gives rise to vaccinia, a localized, non-contagious, mild disease, that in itself causes no mortality, though septic complications may cause some.

  3. 3. Having, by passage, once

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