In examining smears from the noses of patients with acute rhinitis, a spirochete, staining deeply with carbolgentian-violet, was observed in five cases. In four of the cases it was found in connection with infections of the accessory sinuses. In the other cases no history could be obtained except that of a severe acute rhinitis. The spirochete has two or three curves, the ends being pointed and parallel to the long axis; it measures from 2½ to 5 microns in length and ½ micron in width; it is anaerobic and was isolated in pure culture on alkaline goat-blood agar. The growth appeared on the surface after seven days incubation as a dull radiating growth; later it appeared also in the fluid of condensation.
In subcultures it formed raised pin-point colonies near the fluid of condensation, the rest of the growth being dull and rather profuse. The growth in the first
TUNNICLIFF R. A SPIROCHETE ASSOCIATED WITH INFECTIONS OF THE ACCESSORY SINUSES. JAMA. 1913;60(23):1781. doi:10.1001/jama.1913.04340230027012
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