In The Journal, May 18, 1912, appeared a preliminary announcement by Karl von Ruck1 of his discovery of a tuberculin with which he asserted that he could produce immunity to tuberculosis in both man and animals.
Later he issued a pamphlet in which was given briefly his method of making this vaccine and the protocols of his experiments by which he demonstrated immunity. Also in another article2 von Ruck discussed the subject in a little more elaborate way than that taken in his pamphlet.
His tuberculin, or vaccine as he termed it, contained in each cubic centimeter 10 mg. of protein of tubercle bacilli and a small amount of fatty extractives. In children this was injected in doses of from 0.05 c.c. to 0.6 c.c., depending on the age and number of doses given. One or two doses were given, but when two were used neither was so
CUMMINGS RS. ANIMAL EXPERIMENTS WITH VON RUCK'S NEW TUBERCULOPROTEINS. JAMA. 1913;60(25):1936–1937. doi:10.1001/jama.1913.04340250004002
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