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Article
June 21, 1913

SPECIFIC AND EXTREME HYPERLEUKOCYTOSIS FOLLOWING THE INJECTION OF BACILLUS TYPHOSUS IN IMMUNIZED RABBITS

Author Affiliations

BERKELEY, CAL.

From the Hearst Laboratory of Pathology and Bacteriology, University of California.

JAMA. 1913;60(25):1950. doi:10.1001/jama.1913.04340250018010
Abstract

In a previous note1 dealing with induced variations in the agglutinability of the typhoid bacillus, we have indicated a method for testing the protection of animals that have been immunized by various preparations of the typhoid bacillus. This method consists in employing the typhoid-carrier state in rabbits, which, under proper conditions, may be produced regularly in control animals. This carrier state, which is usually followed by the death of the animal in from five to twenty days, does not occur in animals that have been properly immunized against the typhoid bacillus. In a further study of the mechanism by which the injected bacteria are disposed of in the immunized animal, an apparently unrecognized and significant phenomenon has been observed which further emphasizes the importance of polymorphonuclear leukocytes in disposing of bacteria.

The preeminent importance of leukocytes of the polymorphonuclear type in taking care of bacterial infections has been amply

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