Two years ago I published a preliminary report1 on the experimental study of anaphylaxis in cancer. I showed that there is a decided difference in the anaphylactic reaction when guinea-pigs sensitized with blood-serum from a normal individual and other guinea-pigs sensitized with blood-serum from a cancer-bearing individual are both given a final dose of blood-serum from a cancer-bearing individual. Two series of guinea-pigs were used in each experiment. Pigs of Series A were sensitized with normal blood-serum in doses varying from 0.01 to 0.5 c.c. Series B was sensitized with the same amounts of blood-serum from an individual bearing an advanced cancer. After two weeks, when sensitization was established, each pig, of both Series A and Series B, was given an intraperitoneal injection of 5 c.c. of blood-serum from a cancer-bearing individual. The results were decisive. The pigs of Series A, those pigs sensitized with normal blood-serum, had symptoms
RANSOHOFF JL. ANAPHYLAXIS IN THE DIAGNOSIS OF CANCER. JAMA. 1913;61(1):8–10. doi:10.1001/jama.1913.04350010010003
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