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July 12, 1913


JAMA. 1913;61(2):102-105. doi:10.1001/jama.1913.04350020028012

Pemphigus foliaceus was first described by Cazenave in 1844. It is a rare skin disease occurring about once in five thousand cases. Radcliff Crocker, with his almost unlimited experience up to the year 1903, encountered it only six times—in five women and one man. It is one of the rare forms of dermatitis that has a universal distribution, with the formation of flaccid bullae which quickly rupture and discharge their contents, leaving an inflamed, excoriated and fissured surface.

The disease may begin as a pemphigus foliaceus or from a chronic pemphigus vulgaris, the bullae changing their character. It may develop from a dermatitis herpetiformis, according to Hallopeau, or from a general dermatitis exfoliativa.

The bullae are flaccid and at times do not raise the epidermis perceptibly; if the amount of fluid is greater, it extends the lower part of the bullae. The contents are purulent, almost from the beginning. The

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