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July 12, 1913

DIPLOSAL—ITS TOXICITY

JAMA. 1913;61(2):116-117. doi:10.1001/jama.1913.04350020042017
Abstract

Diplosal, or salicylo-salicylic acid (OH.C6H4COO.C6H4COOH), is a compound obtained by the condensation of two molecules of salicylic acid, a phenol group of one molecule reacting with the hydroxyl group of the other molecule with the elimination of water thus forming the salicylic ester of salicylic acid. When decomposed by hydrolysis it takes up water, and 100 parts of diplosal yield 107 parts of the salicylic acid.

This substance was submitted to the Council with the claim that it was superior to salicylic acid and the other salicylates because it was free from all the undesirable side effects of those substances. Diplosal is insoluble in water and nearly so in dilute acids, so that it was assumed by the manufacturers that it would produce no undesirable effects on the stomach. When acted on by alkalies it is decomposed with the formation of an

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