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July 19, 1913

PHENOLSULPHONEPHTHALEIN IN ESTIMATING THE FUNCTIONAL ACTIVITY OF THE KIDNEYS: A FURTHER CONTRIBUTION TO ITS VALUE

Author Affiliations

Surgeon to Beth Israel Hospital, Montefiore Home and Mount Sinai Hospital Dispensary NEW YORK

JAMA. 1913;61(3):184-189. doi:10.1001/jama.1913.04350030024009

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Abstract

In a former paper Dr. Kristeller and I referred to a number of methods that have been devised for the purpose of estimating the sufficiency of the kidney function and have shown wherein they are unsatisfactory and impracticable. Up to that time we had made observations on fifty-eight subjects, giving seventy injections of phenolsulphonephthalein. These observations were made on healthy males and on a series of cases of chronic parenchymatous nephritis, acute diffuse nephritis, chronic interstitial nephritis and a few cases of enlarged prostate. The results obtained warranted the conclusion that the elimination of the drug went hand in hand with the elimination of the normal products of metabolism, a fact for which this method is bound to prove of greater value than any other devised.

We pointed out that phenolsulphonephthalein possesses the following advantages:

1. The drug does not readily decompose in solution and can be sterilized by boiling.

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