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Article
August 2, 1913

CLINICAL EFFECTS OF "NATURAL" AND "SYNTHETIC" SODIUM SALICYLATE"NATURAL"

Author Affiliations

ANN ARBOR, MICH.

JAMA. 1913;61(5):319-321. doi:10.1001/jama.1913.04350050001001
Abstract

A COOPERATIVE INVESTIGATION  It has been claimed that the sodium salicylate prepared from natural oils is superior as a therapeutic agent to the sodium salicylate prepared by synthetic methods. If this claim be justified, then the natural form of the drug should be prescribed by physicians; but if the claim be unsubstantiated, then the additional expense of the natural product is unnecessary and the synthetic drug is to be preferred. The Council on Pharmacy and Chemistry of the American Medical Association has undertaken to investigate various aspects of this question, and papers dealing with the literature,1 the effect of the drug on animals2 and the chemical purity of commercial sodium salicylate3 have already appeared. In determining the relative therapeutic value of the two forms of sodium salicylate, however, clinical evidence of the proper sort is of paramount importance. The efficacy of the drug in relieving pain, and

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