Infection is a contest between two opposing forces: one the invading parasite, the other the resisting host. It is a struggle between two contestants, each displaying great resourcefulness and consummate skill. I propose to lay before you the main facts of this combat in so far as they have been worked out and to draw from them a deduction looking to the better control by improved therapeutic methods of the issue of infection.1
The properties of living things are not fixed, but are subject to certain and sometimes fundamental fluctuations. What are described as biologic variations arise among the very lowly bacteria and protozoa as among the higher types of plant and animal life.2 The character of the variations differs merely because of the minute size and the simplicity of structure of the micro-organisms, while the variations themselves are for the same reasons made more difficult to detect.
FLEXNER S. THE LOCAL SPECIFIC THERAPY OF INFECTIONS: I. THE BIOLOGIC BASIS. JAMA. 1913;61(7):447–452. doi:10.1001/jama.1913.04350070001001
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