Ever since Laennec1 first described cirrhosis of the liver, there has been an immense amount of experimental work done as to the etiology and histology of this disease. Joannovics2 in 1904 gave a summary of the work that had been done up to that time together with a summary of the methods used. Briefly these methods as given by him can be summarized as follows: He divides all previous research into two main classes; one in which the formation and increase of interlobular connective tissue takes place with cirrhosis of the liver, and the other in which degeneration of the liver-cells takes place. He says that all operative interferences whether working on the common bile-duct, the portal vein or the hepatic artery belong to the first class, together with the injection of irritating substances into the common bileduct or into the parenchyma of the liver itself, and also
GROVER AL. EXPERIMENTAL CIRRHOSIS OF THE LIVER. JAMA. 1913;61(7):458–461. doi:10.1001/jama.1913.04350070012004
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