Examination of the spinal fluid has in recent years become of great value in the study of syphilis of the nervous system, particularly in the so-called parasyphilitic conditions, tabes and paresis, which we now know, through the investigations of Noguchi and others, to be not parasyphilitic but due to the invasion of the cerebrospinal system by the Spirochaeta pallida itself.
We undertook the investigation of the cerebrospinal fluid on account of the definite findings that can be demonstrated in it to indicate an invasion of the cerebrospinal system by the Spirochaeta pallida, the purpose being to determine what percentage of patients with syphilis applying for treatment at a general dermatologic clinic would show evidence of spinal invasion.
The large percentage of early syphilis reported in literature as giving evidence of meningeal disturbance encouraged us. All of the cases of syphilis, therefore, in the outpatient department of the Washington University Hospital
ENGMAN MF, BUHMAN R, GORHAM, DAVIS RH. A STUDY OF THE SPINAL FLUID IN ONE HUNDRED CASES OF SYPHILIS: INCLUDING INVESTIGATIONS FOR ARSENIC AFTER INTRAVENOUS ADMINISTRATION OF NEOSALVARSAN. JAMA. 1913;61(10):735–738. doi:10.1001/jama.1913.04350100013005
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