The large number of failures in the treatment of glaucoma may be attributed to only one cause: our ignorance regarding the nature of this disease.
When Mackenzie and von Graefe declared, half a century ago, that the essence of glaucoma lies in the increase of intra-ocular pressure, they proclaimed only a small part of the truth. The increase of intra-ocular pressure is a symptom constantly accompanying glaucoma, but it is not the essence of glaucoma. Even the zealous researches of Knies, Weber, Priestly Smith, Laqueur, Brailey and others could not advance much further the problem relating to the nature of glaucoma. The general trend has been and still is to detect the ocular changes which produce the increased intra-ocular pressure in glaucoma, but little has been done in the direction of investigating the general causes which bring about these changes.
In the light of newer methods of investigation and of
SCHOENBERG MJ. EXPERIMENTAL STUDY OF INTRA-OCULAR PRESSURE AND OCULAR DRAINAGE. JAMA. 1913;61(13_part_2):1098–1103. doi:10.1001/jama.1913.04350140014004
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