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November 1, 1913


JAMA. 1913;61(18):1632-1636. doi:10.1001/jama.1913.04350190050023

RENAL DIABETES  Although the existence of glycosurias due to changes in the kidneys, particularly as a result of the administration of drugs like phloridzin, is well established in an experimental way, as much cannot be said in respect to the clinical cases of glycosuria which occur in man. The possibility of a renal diabetes involving an increased permeability of the kidneys analogous-to phloridzin glycosuria has been suspected and has found advocates at various times since the first suggestions of Lépine1 and Klemperer2 in this direction. As the cases were critically studied, however, the proofs of the specific functioning of the kidneys in the pathogenesis of the glycosuria in most instances failed. It is undisputed that the development of renal lesions, especially chronic interstitial nephritis, in a diabetic may greatly reduce the excretion of sugar in the urine. That the reverse effect, that is, the elimination of sugar as

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