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Article
November 8, 1913

THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1913;61(19):1720-1723. doi:10.1001/jama.1913.04350200046016
Abstract

A NEW INDICATOR OF PATHOLOGIC TISSUE CHANGES  In the modern investigation of neoplasms which is being pursued so vigorously it has been of fundamental importance to ascertain the specific peculiarities of the abnormal tissues. When once it is made clear precisely wherein pathologic growths differ from the normal tissues which they accompany or supplant, and what are the stimuli which initiate and promote their development, a great step in advance will have been taken. So far as the morphologic features are concerned much valuble information has long been at hand; but after all, structural anomalies are merely the formal expression of alterations due to physical or chemical changes either within the cells themselves or in their immediate environment. The solution of the underlying problems of the development of neoplasms is closely bound up with the knowledge of the inciting causes. The possibility of an artificial inhibition or retrogression of such

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