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Article
December 13, 1913

THE ETIOLOGY AND VACCINE TREATMENT OF HODGKIN'S DISEASE: PRELIMINARY NOTE

Author Affiliations

CHICAGO

From the Medical Clinic of Rush Medical College, and the Memorial Institute for Infectious Diseases, Chicago.

JAMA. 1913;61(24):2122-2123. doi:10.1001/jama.1913.04350250008003
Abstract

This note is published at this time as a confirmation of the findings in Hodgkin's disease of Bunting and Yates,1 and Negri and Mieremet,2 and to call attention to the apparently marked benefit following injections of the heat-killed organisms found in the lymph-nodes.

A Gram-staining, non-acid-fast, polymorphous diphtheroid bacillus corresponding to the one found by Fränkel and Much3 in smears, and cultivated successfully by Bunting and Yates and Negri and Mieremet has now been isolated from the lymph-nodes in twelve cases of Hodgkin's disease. It was obtained in pure culture in only three cases, while in the rest it appeared in conjunction with a staphylococcus. Whenever possible, a portion or all of two lymph-nodes were removed, one from the group involved the longest (usually the cervical region), and one from the group most recently involved (usually the inguinal region). In addition to planting small pieces of the

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