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Article
December 13, 1913

ISOLATION OF A NEW VASOCONSTRICTOR SUBSTANCE FROM THE BLOOD AND THE ADRENAL CORTEX: PRESENCE OF THE SUBSTANCE IN THE BLOOD AND ITS ACTION ON THE CARDIOVASCULAR APPARATUS

Author Affiliations

Associate Professor of Pharmacology; Instructor in Medicine, Johns Hopkins University BALTIMORE

JAMA. 1913;61(24):2136-2138. doi:10.1001/jama.1913.04350250022006
Abstract

In the course of some investigations on the effect of Eck's fistulas on dogs, about three years ago, we were impressed by the fact that the dehepatization or extirpation of the liver, after an anastomosis had been established between the vena cava and portal vein of such animals, was followed by a train of symptoms very much resembling those of poisoning by digitalis-like bodies; namely, high blood-pressure, powerful cardiac stimulation and often a final standstill of the heart in systole. It occurred to us that these symptoms might be due to some substance normally present in the blood which is destroyed by the liver and is found in the blood in larger quantities after extirpation of that organ. We therefore attempted to isolate the substance responsible for such an action from normal mammalian blood, in the following manner:

Defibrinated blood or serum of oxen and pigs was treated with dehydrated

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