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Article
December 20, 1913

THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1913;61(25):2244-2247. doi:10.1001/jama.1913.04350260042018
Abstract

THE RESISTANCE OF VARIOUS NERVE-CELLS TO ANEMIA  The nervous system of higher animals is exceedingly sensitive to anemia or other physiologic conditions which involve a local lack of oxygen. Muscle tissue which has been supplied inadequately with this essential element or perhaps completely deprived of it for not inconsiderable periods of time may still show a satisfactory recovery of contractile power when the circulation is suitably restored and the resuscitating oxygen reaches the asphyxiated tissue-cells, but this is not the case with the nervous tissues. The nerve-cells of different classes and positions show differences in sensitiveness to anemia. Those of the cerebrum and cerebellum are unquestionably most readily damaged by oxygen starvation. There is evidence to show, for example, that eight minutes of complete anemia may permanently eliminate the function of some of the cells of the cortical areas. If the blood-supply there is wanting for more than twenty minutes

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