The introduction of various therapeutic agents into the spinal canal in attempts to cure neural syphilis is a comparatively new procedure. In spite of over five years of its rather general employment, however, and the varied series of reported cases by many workers, its exact status is still somewhat uncertain. The demonstration by Noguchi and Moore1 in 1913 of Spirochaeta pallida in stained sections from the brain tissue of persons who had died of general paresis, and the close relation between this condition and tabes dorsalis, leave little doubt as to the causative agent in these diseases. To Swift and Ellis,2 however, belongs the credit for the really remarkable discovery of the efficacy of intraspinal therapy in certain types of syphilitic involvement of the cerebrospinal system.
Through the observations of Taege,3 who noted that the milk of a syphilitic mother, under salvarsan therapy, had a markedly curative
WATSON EM. THE PLACE OF INTRASPINAL THERAPY IN UROLOGY. JAMA. 1918;70(5):296–300. doi:https://doi.org/10.1001/jama.1918.02600050018009
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