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From the JAMA Network
March 3, 2015

The Link Between Dietary Sugar Intake and Cardiovascular Disease Mortality: An Unresolved Question

Author Affiliations
  • 1Department of Nutritional Sciences, Texas Tech University, Lubbock
  • 2Center for Quantitative Obesity Research, Department of Mathematical Sciences, Montclair State University, Montclair, New Jersey
JAMA. 2015;313(9):959-960. doi:10.1001/jama.2014.18267

In the April 2014 issue of JAMA Internal Medicine, Yang et al1 summarized findings from NHANES from 1988 to 2010 showing that there was relatively little change in the consumption of added sugar in terms of the proportion of total calories consumed. At the beginning of the study period (1988-1994), 15.7% (95% CI, 15.0%-16.4%) of the total calories consumed were from added sugar (approximately 350 kcal/day), and 14.9% (95% CI, 14.2%-15.5%) of calories consumed were from added sugar (approximately 326 kcal/day) at the end of the observation period (2005-2010). With nearly 15 years of follow-up, there was a significant dose-dependent relationship between reported ingestion of added sugar and cardiovascular (CVD) mortality. These findings were consistent across subpopulations, and after adjusting for confounding factors, the associations were strengthened. These observations are interesting because during a time period when the prevalence of obesity was increasing,2 added sugar consumption was relatively stable. However, individuals who reported more than 25% of their total intake as added sugar did have greater CVD mortality (adjusted hazard ratio of 2.75).

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