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Lab Reports
March 3, 2015

Oxytocin Restores Sociability in a Mouse Model of Autism

JAMA. 2015;313(9):885. doi:10.1001/jama.2015.1189

New research indicates that oxytocin, a neuropeptide associated with the development of social bonds, can markedly improve social behavior in a validated knockout mouse model of a monogenic form of autism spectrum disorder (Peñagarikano O et al. Sci Transl Med. 2015;7[271]:271ra8).

A team led by investigators at the University of California, Los Angeles, found that juvenile knockout mice administered a single acute dose of oxytocin showed improvements in social behavior that lasted for 2 hours after treatment.