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March 16, 1918


JAMA. 1918;70(11):780-781. doi:10.1001/jama.1918.02600110038014

The more recent quantitative microchemical studies of the blood have indicated that among the nonprotein nitrogenous constituents the estimation of creatinin is likely to be of especial service from a diagnostic and prognostic standpoint. There are few, if any, normal nitrogenous components of the urine for which the kidneys are more permeable; so that when creatinin begins to accumulate in undue proportions in the circulating blood, there can be little question as to the seriousness of the finding.

But what constitutes an abnormally high content of creatinin in the blood? Folin and Denis placed the normal limits at from 1 to 1.4 mg. per hundred c.c.; according to Myers and Fine, who have accumulated exceptionally extensive statistics on this question, the range is set at from 1 to 2 mg. Other investigators have been in essential accord with such figures. Only Gettler and Baker1 indicate 0.5 mg. as the