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In the first chapter of "The Integrative Action of the Nervous System," Sherrington enumerated eleven salient "characteristic differences between conduction in nerve trunks and conduction in reflex arcs" (the central nervous system). In the present volume, Lucas has made an attempt to gain an insight into conduction in the central nervous system by an analysis of analogous phenomena in conduction along peripheral nerves with the hope that the remarkable and puzzling phenomena so characteristic of the activity in the complex central nervous system might find a ready explanation in terms of what can be learned from a study of the phenomena occurring during conduction along the nerve of a more simple nerve-muscle preparation. In Lucas' own words: "The question I wish to discuss is not why the nerve conducts, but how it conducts, and how far the phenomena of conduction in a peripheral nerve may be made the basis of
The Conduction of the Nervous Impulse. JAMA. 1918;70(11):803–804. doi:https://doi.org/10.1001/jama.1918.02600110061026
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