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These British officers describe the clinical features in 150 cases of trench nephritis observed during the early stages in a casualty clearing station. They also record the results of pathologic examination of cases which terminated fatally within the first three weeks of the disease. They were all cases presenting constitutional symptoms as well as albuminuria, no cases being included of the prevalent albuminuria without indisposition, and none of the so-called "lower tract" cases. All the patients were employed in the forward area and the great majority actually in the trenches. There was commonly no history of any predisposing illness, nor were there any concurrent epidemics, such as scarlet fever or tonsillitis, which could be considered to bear on the etiology of the disease. The seasonal incidence showed a marked increase during the winter months.
The cases were observed during the early part of 1916, and the entire following winter.
TYTLER WH, RYLE JA. CLINICAL AND PATHOLOGIC NOTES ON TRENCH NEPHRITIS. JAMA. 1918;70(14):998–999. doi:https://doi.org/10.1001/jama.1918.26010140009011d
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