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April 27, 1918


Author Affiliations


From the Department of Pathology, University of Cincinnati College of Medicine.

JAMA. 1918;70(17):1208-1209. doi:10.1001/jama.1918.02600170008003

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There is some factor at work in the course of a convulsion that brings it on and again stops it. That the convulsion stops is an argument in itself against the belief that a chemical substance reaches such a concentration as directly to produce the convulsion. If there is in the blood a chemical, the concentration of which increases to a point at which it produces a convulsion, does its decrease in concentration or disappearance permit the convulsion to end? From the following observations we may think of the chemical as only producing an edema of the brain. The chemical continues as an increasing factor, and the balance between the intracranial pressure and the blood pressure, the variable.

It is well known that the blood pressure is a function of the intracranial pressure, rising directly with it. Normally the blood pressure is higher than the intracranial pressure. The height of

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