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April 27, 1918


Author Affiliations

Lewis-Gale Hospital, Roanoke, Va.

JAMA. 1918;70(17):1254-1255. doi:10.1001/jama.1918.02600170054030

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To the Editor:  —Having read a report by Dr. James C.. Sargent of Milwaukee on five cases of unusual toxicity resulting from administration of the new American made salvarsan, I am constrained to report three cases, believing that this information should be given to the medical profession.A man, aged 38, suffering from the secondary stage of syphilis, who had had three weekly 0.6 gm. doses of diarsenol with no toxic reactions following, reported for his fourth treatment. The first obtainable American made salvarsan had just reached us, and a dose of this was given after being mixed in the following manner: First the ampule was dissolved in 90 c.c. of hot sterile freshly distilled water, and sufficient cool freshly distilled water was added to bring the amount up to a 200 c.c. bulk. Freshly prepared 15 per cent. sodium hydroxid was added drop by drop, the solution being stirred

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