On account of the lack of conclusive available data on the virulence of tubercle bacilli in the sputum of consumptives, and the tremendous importance of this information for the institution of hygienic measures in preventing and eradicating the disease, it was deemed advisable to investigate this problem. The earlier literature on this subject deals with it pro and con, but is not clear cut and decisive, lacking substantiating experiments. From this literature, however, there are several conspicuous considerations which must be kept in view in performing experiments to determine the virulence of tubercle bacilli. Fraenkel and Baumann1 found guinea-pigs alone (not rabbits, rats or mice) to be available for revealing differences in pathogenic properties of tubercle bacilli. Marmorek2 calls attention to the fact that as a criterion of the infectious power of tubercle bacilli it is necessary to note the distribution of the anatomic lesions, and only in
CORPER HJ. ARE ALL THE TUBERCLE BACILLI FOUND IN THE SPUTUM VIRULENT? JAMA. 1918;70(18):1281–1282. doi:https://doi.org/10.1001/jama.1918.02600180009003
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