In a preliminary report,1 I described a new method for the estimation of the total volume of blood in anemia.
In no disease is it of greater importance to know the volume of blood in the body than in pernicious anemia. We find patients in this disease bearing their illness variably, though the degree of anemia in all may be the same. In many the same group of symptoms are present, varying only in intensity. I believe that individual peculiarities may account for differences in the intensity of symptoms, and that also some differences may possibly be accounted for by varying degrees of toxicity; nevertheless, the main factor, in my opinion, is the hitherto unrecognized importance of blood volume.
Rancke has demonstrated that the blood is thus distributed in the various organs: In the rabbit, onefourth to the heart, lungs and great vessels; one-fourth to the resting muscles, and
LINDEMAN E. THE TOTAL BLOOD VOLUME IN PERNICIOUS ANEMIA. JAMA. 1918;70(18):1292–1297. doi:https://doi.org/10.1001/jama.1918.02600180020008
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