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[The foregoing communication was referred to Dr. Noguchi, who replies:]
To the Editor:
—In reply to the criticism of Dr. J. J. Seelman, who has expressed apprehension with regard to the reliability of the serodiagnostic procedure described by me in The Journal, I wish to make the following statement:Dr. Seelman regards my proposed method as less accurate in its quantitative aspect than the Wassermann system because of the variation in complement in different human serums, but he apparently ignores the inherent source of error in the latter from the varying amounts of natural antisheep amboceptor present in various human serums. Now, whereas ninety out of a hundred serums contain a practically constant quantity of complement, and no hypercomplementary serum contains more than twice this average complement content, the amount of natural antisheep amboceptor varies from none to as many as twenty units or more. In the homohemolytic system only
Noguchi H. "SERUM DIAGNOSIS OF SYPHILIS"-Reply. JAMA. 1918;70(20):1487–1489. doi:https://doi.org/10.1001/jama.1918.02600200052025
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