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June 15, 1918


JAMA. 1918;70(24):1866-1867. doi:10.1001/jama.1918.02600240062014

The average normal person ingests several hundred grams of digestible carbohydrate every day. Whether in the form of sugars, dextrins or starches this quota is utilized quite perfectly; at any rate it leaves the alimentary tract and disappears in the processes of metabolism. Glucose is always circulating in the blood stream. It has long been recognized that traces of sugar or sugar-like reducing substances occur in the excreta of healthy persons. They can be detected by refined methods of examination and have in part been identified as glucose. Hence one reads in textbooks that "the kidney is not a perfect filter, and small amounts of glucose can penetrate it. The appearance of enough dextrose to give a precipitate of cuprous oxid in the Fehling test is abnormal."1

Stanley Benedict2 and his collaborators at the Cornell University Medical College, New York City, working in cooperation with the Harriman Research