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Article
June 15, 1918

SERUM DIAGNOSIS OF SYPHILIS

JAMA. 1918;70(24):1879. doi:10.1001/jama.1918.02600240075020

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Abstract

To the Editor:  —May I point out some fallacies in Dr. Noguchi's answer to my criticism of his proposed new method of performing the Wassermann test in Army and Navy laboratories?It is true that the presence of native antisheep amboceptors in human serum may cause errors in the Wassermann test when performed with a sheep hemolytic system. His statement, however, that this factor is uncontrollable is not correct. As a matter of fact I am quite certain that most careful workers who use the sheep hemolytic system remove the native antisheep amboceptors from serum before testing it.Dr. Noguchi frankly admits that with his method a moderately positive serum containing an excess of native complement may give a weaker reaction than would a serum with an average amount of complement. Then by what process of reasoning can he reach the conclusion that a weakly positive serum may not give

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