The infrequency with which arsenic has been found in the cerebrospinal fluid, following the intravenous injection of arsphenamin, forces the conclusion that this dye does not as a rule pass from the blood into the cerebrospinal spaces. Barbat1 believes that the transition is aided by drainage of the lumbar cistern shortly after the injection. By this technic, he was able at the end of twenty-four hours to demonstrate 0.25 part of arsenic per million in twenty-three fluids of twenty-six examined. His deduction, however, is vitiated by the fact that, as early as twenty minutes after the intravenous injection, and unaided by the auxiliary puncture, 42 per cent. of the fluids examined showed 0.20 part of arsenic per million, which is practically as much as was found in twenty-four hours.
The results reported in Table 1 are based on an examination of 123 cerebrospinal fluids collected from random neurosyphilitic patients,
RIEGER JB, SOLOMON HC. THE CIRCULATION OF ARSENIC IN THE CEREBROSPINAL FLUID. JAMA. 1918;71(1):15–17. doi:https://doi.org/10.1001/jama.1918.02600270017006
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