While dogmatism has no place in medicine, it is especially unfortunate in the weighing of evidence and the evaluation of data in the tentative endeavor now being made to determine the most efficient form of therapy for the treatment of neurosyphilis. Cotton manifests the true scientific spirit when he says that with a spirit of open-mindedness every method should be given a thorough trial, and that it is only by continual experimenting with new ideas that we can hope for progress in this new line of endeavor. If an apology were necessary because of my selection of this much discussed subject, it were best made in the words of Southard: "That no more important human problem now exists than syphilis, and that neurosyphilis is a highly important fraction of the total problem."
The three principal methods of procedure in the treatment of nervous syphilis are intraspinal, intracranial (subdural or intraventricular)
RIGGS CE. SOME FURTHER CONSIDERATIONS CONCERNING THE TREATMENT OF NEUROSYPHILIS. JAMA. 1918;71(3):159–162. doi:https://doi.org/10.1001/jama.1918.02600290001001
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