The subject of the etiology of parotitis has been investigated from a bacteriologic standpoint, and cocci have been isolated from the blood, saliva, and fluid aspirated from the swollen parotid gland.1 Attempts to reproduce parotitis in animals by the inoculation of such cocci proved entirely unsuccessful, showing that these earlier studies had not solved the problem of the etiology of mumps. The cocci are probably contaminations. In 1908, Granata2 first used saliva filtrate from parotitis patients for animal inoculation, suggesting that the virus of parotitis may be a filterable one. Since then investigators have tried to reproduce the disease in laboratory animals rather than to isolate a bacterium from human patients. Granata worked with rabbits; Gordon3 inoculated monkeys intracerebrally. Nicolle and Conseil4 injected material into the parotid glands of monkeys. The results of all these investigations were only suggestive as far as the reproduction of mumps
WOLLSTEIN M. AN EXPERIMENTAL STUDY OF PAROTITIS. JAMA. 1918;71(8):639–644. doi:https://doi.org/10.1001/jama.1918.02600340031009
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