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Article
August 31, 1918

REPORT OF A SEVERE CASE OF EPIDEMIC MENINGITIS TREATED BY THE COMBINED INTRAVENOUS AND INTRASPINAL ADMINISTRATION OF ANTIMENINGOCOCCUS SERUM.

Author Affiliations

(Wallace, Ind.) Captain, M. R. C., U. S. Army Camp Logan, Houston, Texas

JAMA. 1918;71(9):745. doi:10.1001/jama.1918.26020350018011d

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Abstract

Lieutenant M. was admitted April 25, 1918, and a diagnosis of epidemic meningitis was confirmed by laboratory methods. He was given 30 c.c. of antimeningococcus serum intraspinally daily for seven consecutive days with but slight improvement. On the seventh day he was given 30 c.c. of undiluted serum intravenously, and the same amount on the following day combined with the same sized dose intraspinally.

The patient showed marked improvement, but developed a severe anaphylaxis. No more serum was given for two days, nothing being done during this time except the withdrawal of from 60 to 80 c.c. of spinal fluid to relieve pressure.

On the eleventh day the patient was seized with a hard chill followed by a rise in temperature to 103 and all the former symptoms. The spinal fluid again became cloudy. He was given 15 c.c. of serum intraspinally, and one hour later 60 c.c. were given

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