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September 14, 1918


JAMA. 1918;71(11):875-878. doi:10.1001/jama.1918.02600370013006

Exophthalmic goiter in pregnancy is rare, owing to the restraining influence the disease exerts on conception. Halliday-Croom1 reports only one case in 15,000 dispensary patients, while in his private practice he found twelve cases, causing him to believe that this complication is more prevalent among the upper classes. Bonnaire2 found two cases in 30,000 dispensary patients. Seitz3 in 1913 was able to collect 112 cases from his own material, literature and circular letters. Additional cases have been reported by Gellhorn,4 Ward,5 Markoe,6 Crotti,7 Davis,8 Porter,9 Stowe10 and others.

I want to report seven cases of toxic goiter with exophthalmos and nine cases of toxic nonexophthalmic goiter occurring during pregnancy, seen during the past five years.

I believe that occasionally patients with goiter of brief duration ascribe their increase in symptoms at pregnancy to the pregnancy itself, while in reality the